专利名称：Pharmaceutical composition useful for the
treatment of hypercholesteremia
发明人：Kuron, Gunther W.申请号：EP79104025.6申请日：19791018公开号：EP0010299B1公开日：19840215
摘要：Pharmaceutical composition, useful for the treatment of hypercholesteremia inmammals, especially humans, comprising (a) a cholesterol synthesis inhibitor acting at theHMG-CoA reductase level with an EO50 less than 10<-><6>, such as a 6-[2-(8-substituted-2-methyl-1,2,6,7,8,8a -hexahydro-1-naphthyl) ethyl]-4-hydroxy-4, 5- dihydro-2-pyrone or a 4R trans-6-phenyl-E-4- hydroxytetrahydropyran-2-one in which E is a bond,a C1-3 alkylene or-CH=CH-and (b) a non-toxic anion exchange resin in the weight ratio of1:0.08 to 1:15,000. The resin preferably is a styrene-divinylbenzene copolymer containingquaternary ammonium groups. When present in the indicated weight ratios, synergismexists between the cholesterol synthesis innibitor and the anion exchange resin. Thecomponents can be present separately for separate dosages or, preferably, as a unitarycombination. The effects of treatments with compound II (Compactin) and withcholestyramine, separately and in combination, are illustrated by figure 1.
申请人：Merck & Co., Inc.
地址：126, East Lincoln Avenue P.O. Box 2000 Rahway New Jersey 07065-0900 US
国籍：US
代理机构：Abitz, Walter, Dr.-Ing.
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