专利名称：Methods for the production of highly
sensitive and specific cell surface probes
发明人：Weihong Tan,Dihua Shangguan,Ying Li申请号：US11708760申请日：20070220
公开号：US20090130650A1公开日：20090521
专利附图：
摘要：A system and method for producing an oligonucleotide having a high affinity forextracellular or cell surface markers on a target cell. The resultant oligonucleotideprobe can be used to detect a target biomolecule, in particular a cancer cell or infectious
agent such as a bacterium, virus, or fungus, comprising an aptamer having a high affinityfor the biomolecule, wherein at least one labeled dye is attached to the aptamer. Thelabeled dye causes the aptamer to emit a baseline, non-visible emission. When theaptamer (also referred to herein as a probe) of the invention interacts with a targetbiomolecule, the fluorescence emission changes from the baseline emission to anemission that is visually detectable.
申请人：Weihong Tan,Dihua Shangguan,Ying Li
地址：Gainesville FL US,Beijing CN,Gainesville FL US
国籍：US,CN,US
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