专利名称：(HET)ARYL-P-QUINONE DERIVATIVES FOR
TREATMENT OF MITOCHONDRIAL DISEASES
发明人：Andrew W. HINMAN,Kieron E. WESSON申请号：US14586516申请日：20141230
公开号：US20150297551A1公开日：20151022
摘要：Methods of treating or suppressing mitochondrial diseases, such as Friedreich'sataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy,encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), aredisclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolicstate of a subject and the efficacy of treatment are also disclosed. Methods of
modulating, normalizing, or enhancing energy biomarkers, as well as compounds usefulfor such methods, are also disclosed.
申请人：Edison Pharmaceuticals, Inc.
地址：Mountain View CA US
国籍：US
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