专利名称:2-ARYLIMIDAZOLES
发明人:ERICH MULLER,NORBERT HAUEL,KLAUS
NOLL,BERTHOLD NARR,JOACHIMHEIDER,MANFRED PSIORZ,ANDREASBOMHARD,JACQUES VAN MEEL,WILLIDIEDEREN
申请号:AU5893286申请日:19860620公开号:AU5893286A公开日:19861224
摘要:2-Arylimidazoles of the formula in which R denotes a hydrogen atom or analkyl group, Ar denotes a group of the formula A and B together with the two carbonatoms in between denote a group of the formula in which R1 denotes an alkylsulphenyl,alkylsulphinyl, alkylsulphonyl or alkylsulphoximino group, an alkylsulphoximino groupsubstituted on the nitrogen atom by an alkanoyl, alkylsulphonyl or hydroxycarbonyl-alkylenecarbonyl group, an ethoxy or n-propoxy group which is in each case terminallysubstituted by an alkylsulphenyl, alkylsulphinyl, alkylsulphonyl or alkylsulphoximinogroup, an alkoxycarbonylamino or N-alkylaminocarbonylamino group, or also in the 4-position, a hydroxyl, phenylalkoxy, aminosulphonyl, alkylsulphonyloxy or
alkylsulphonylamino group, R2 denotes a hydrogen atom or an alkoxy group, R3 denotesan ethoxy or n-propoxy group which is in each case terminally substituted by an
alkylsulphenyl, alkylsulphinyl, alkylsulphonyl or alkylsulphoximino group, R4 denotes analkyl, alkoxycarbonyl, alkanoyl, N-alkanoylaminomethyl, benzoyl, phenylmethoxymethyl,
aminocarbonyl, cyano, trifluoromethyl, aminosulphonyl, N-alkylaminocarbonylamino orN-alkyl- N-alkylaminocarbonylamino group, R5 denotes a hydrogen or halogen atom oran alkyl or cyano group and R6 denotes a hydrogen atom or an amino group, and thecompounds 5-cyano-2-(4'-methanesulphonylamino-2'-methoxyphenyl)- benzimidazole,4-methyl-2-(4'-methanesulphonyloxy-2'-methoxyphenyl)- benzimidazole, 4-cyano-2-(4'-methanesulphonyloxy-2'-methoxyphenyl)-benzimdazole, 4-aminocarbonyl-2-(4'-methanesulphonyloxy-2'-methoxyphenyl)- benzimidazole and 4-methoxycarbonyl-2-(4'-methanesulphonyloxy-2'-methoxyphenyl)- benzimidazole, and their tautomers, if Rrepresents a hydrogen atom, and their acid addition salts. The compounds and theirphysiologically tolerated acid addition salts have useful pharmacological properties, inparticular an effect on the blood pressure and on the contractility of the heart muscle aswell as antithrombotic effects and can be prepared by processes known per se.
申请人:THOMAE, DR. KARL G.M.B.H.
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